Lille Score Calculator

The Lille score is a prognostic model used after a course of corticosteroid therapy in severe alcohol-associated hepatitis. It combines baseline patient characteristics with the change in bilirubin during treatment. Its main purpose is to identify patients who are unlikely to benefit from continuing corticosteroids, helping a specialist balance potential benefit against infection and other treatment risks. The model uses age, day-zero albumin, day-zero bilirubin, day-seven bilirubin, prothrombin time, and the presence of renal insufficiency. This calculator expects albumin in grams per liter and bilirubin in micromoles per liter. It computes the published linear term and converts it with a logistic function to a score between zero and one. A falling bilirubin contributes toward a lower score, while limited improvement generally moves the result upward. A conventional cutoff of 0.45 separates likely responders from likely non-responders. Lower scores are associated with a more favorable response and prognosis, while scores above the cutoff suggest poor response. Some clinical discussions further divide results into ranges, but any threshold must be interpreted within the protocol being followed. The score estimates risk at a population level and cannot predict an individual outcome with certainty. Accurate timing and units matter. The follow-up bilirubin should correspond to the treatment interval defined by the clinical protocol, and all values should come from reliable records. Renal insufficiency must be coded according to the model's clinical definition rather than guessed from a single isolated result. Unit conversion errors, especially entering milligrams per deciliter instead of micromoles per liter for bilirubin, can substantially distort the answer. The Lille score is intended for a specific population with severe alcohol-associated hepatitis who have started corticosteroids. It is not a screening test for alcohol-related liver disease, a diagnostic score, or a substitute for assessing infection, bleeding, kidney injury, encephalopathy, nutrition, alcohol withdrawal, or transplant eligibility. Management should involve clinicians experienced in acute liver disease. This educational calculator should support, never replace, verified clinical software, institutional guidance, multidisciplinary review, and direct discussion with the treating hepatology team.