Carboplatin Dose Calculator

Carboplatin is a platinum chemotherapy medicine whose exposure is strongly influenced by renal clearance. AUC-based dosing aims for a target area under the concentration-time curve rather than relying only on body surface area. The Calvert formula calculates dose in milligrams as target AUC multiplied by GFR plus 25. The constant represents estimated nonrenal clearance. This calculator accepts a renal function value directly or estimates creatinine clearance with the Cockcroft-Gault equation. For men, the estimate is age subtracted from 140, multiplied by weight in kilograms, and divided by 72 times serum creatinine in mg/dL. The conventional female adjustment multiplies that result by 0.85. Cockcroft-Gault estimates creatinine clearance and is not identical to measured GFR or laboratory eGFR. The appropriate renal function method must follow the oncology protocol and institutional policy. Small input differences can materially change a cytotoxic dose. Verify that serum creatinine uses mg/dL, weight uses kilograms, and renal function uses mL/min. Some protocols specify actual, ideal, or adjusted body weight, a minimum serum creatinine, or a maximum renal function cap. Those choices are not interchangeable and this general calculator does not automatically impose them. Current laboratory values, collection timing, assay standardization, unstable kidney function, amputation, edema, cachexia, and extremes of body size can reduce the reliability of an estimate. Target AUC depends on regimen, treatment intent, prior therapy, combination medicines, cycle, marrow reserve, and toxicity history. It must come from an authorized treatment protocol, not from the calculator. A mathematically correct result can still be clinically inappropriate. Clinicians should evaluate blood counts, kidney function trends, previous adverse effects, performance status, and local dose-adjustment guidance. The displayed dose is rounded to the nearest milligram for readability. Preparation and administration may require protocol-specific rounding, vial-size handling, pharmacy checks, and independent verification. Never use an unverified web result as a prescription or administration instruction. Patients should not calculate or change their own chemotherapy dose. This tool is educational decision support for qualified professionals. It does not account for every regimen rule and does not replace oncology pharmacy review, institutional systems, prescribing authority, or clinical judgment. Any discrepancy should be resolved against the current approved protocol and patient record before treatment.